Movement Disorders (revue)

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Alterations of striatal neurons in benign hereditary chorea

Identifieur interne : 003A76 ( Main/Exploration ); précédent : 003A75; suivant : 003A77

Alterations of striatal neurons in benign hereditary chorea

Auteurs : Galit Kleiner-Fisman [États-Unis] ; Noel Y. Calingasan [États-Unis] ; Mary Putt [États-Unis] ; June Chen [États-Unis] ; M. Flint Beal [États-Unis] ; Anthony E. Lang [Canada]

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RBID : Pascal:06-0001066

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English descriptors

Abstract

Benign hereditary chorea (BHC) recently has been associated with mutation in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of intemeurons whose tangential migration is mediated by TITF-1. There was a loss outmost TITF-1-mediated striatal intemeurons in the BHC specimen compared to four matched control brains.


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Le document en format XML

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<div type="abstract" xml:lang="en">Benign hereditary chorea (BHC) recently has been associated with mutation in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of intemeurons whose tangential migration is mediated by TITF-1. There was a loss outmost TITF-1-mediated striatal intemeurons in the BHC specimen compared to four matched control brains.</div>
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