Alterations of striatal neurons in benign hereditary chorea
Identifieur interne : 003A76 ( Main/Exploration ); précédent : 003A75; suivant : 003A77Alterations of striatal neurons in benign hereditary chorea
Auteurs : Galit Kleiner-Fisman [États-Unis] ; Noel Y. Calingasan [États-Unis] ; Mary Putt [États-Unis] ; June Chen [États-Unis] ; M. Flint Beal [États-Unis] ; Anthony E. Lang [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2005.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Benign hereditary chorea (BHC) recently has been associated with mutation in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of intemeurons whose tangential migration is mediated by TITF-1. There was a loss outmost TITF-1-mediated striatal intemeurons in the BHC specimen compared to four matched control brains.
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Alterations of striatal neurons in benign hereditary chorea</title>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
<term>Chorea</term>
<term>Nervous system diseases</term>
<term>Neuron</term>
<term>Projection</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée syndrome</term>
<term>Neurone</term>
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<front><div type="abstract" xml:lang="en">Benign hereditary chorea (BHC) recently has been associated with mutation in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of intemeurons whose tangential migration is mediated by TITF-1. There was a loss outmost TITF-1-mediated striatal intemeurons in the BHC specimen compared to four matched control brains.</div>
</front>
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<name sortKey="Calingasan, Noel Y" sort="Calingasan, Noel Y" uniqKey="Calingasan N" first="Noel Y." last="Calingasan">Noel Y. Calingasan</name>
<name sortKey="Chen, June" sort="Chen, June" uniqKey="Chen J" first="June" last="Chen">June Chen</name>
<name sortKey="Flint Beal, M" sort="Flint Beal, M" uniqKey="Flint Beal M" first="M." last="Flint Beal">M. Flint Beal</name>
<name sortKey="Putt, Mary" sort="Putt, Mary" uniqKey="Putt M" first="Mary" last="Putt">Mary Putt</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
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